Positive regulation of chondrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of chondrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V1E1, BLOC1S3, and SDHAF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chondrocyte differentiation activity versus ATP6V1E1 in BLOOD_Leukemia (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ATP6V1E1 →	+0.455	+1.257	.006	.004	2	5
KIDNEY	BLOC1S3 →	+0.971	+0.200	.007	.007	3	3
KIDNEY	SDHAF1 →	+0.576	+0.230	.004	<.001	3	3
KIDNEY	STRN4 →	+1.007	+0.230	.006	<.001	3	3
KIDNEY	CCDC9 →	+1.253	+0.230	.001	<.001	3	3
KIDNEY	PPP4R4 →	-1.162	-0.232	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032332 vs ATP6V1E1 — BLOOD_Leukemia

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