Serine transport

Across TCGA patient cohorts, RNA activity of the Serine transport pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A4, CSGALNACT2, and NID2, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serine transport activity versus SLC1A4 in UVM (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	SLC1A4 →	+1.590	+0.058	<.001	<.001	3	25
UVM	CSGALNACT2 →	+1.058	+0.043	<.001	<.001	3	24
DLBC	NID2 →	+1.575	+0.081	<.001	<.001	3	24
UVM	MAN2A1 →	+1.252	+0.064	<.001	<.001	3	23
ACC	CHSY1 →	+1.536	+0.062	<.001	<.001	3	22
MESO	TOMM40P4 →	+0.834	+0.054	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032329 vs SLC1A4 — UVM

Explore this scatter interactively →