Serine transport

Across TCGA patient cohorts, RNA activity of the Serine transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCNB2, MAPK9, and MED13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serine transport activity versus CCNB2 in UCEC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCNB2 →	-0.526	-0.101	.005	<.001	3	5
OV	MAPK9 →	+0.462	+0.078	.002	.007	3	5
LSCC	MED13 →	-0.238	-0.087	<.001	<.001	3	5
HNSC	ACTN1_S172 →	+0.526	+0.064	.002	.002	3	5
CCRCC	SH3PXD2B →	+0.297	+0.041	<.001	<.001	3	4
UCEC	TPX2 →	-0.536	-0.063	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032329 vs CCNB2 — UCEC

Explore this scatter interactively →