Serine transport

Across TCGA patient cohorts, RNA activity of the Serine transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P4HA3, SLC1A5, and ANTXR2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serine transport activity versus P4HA3 in OV (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	P4HA3 →	-0.843	-0.199	.004	.005	2	6
LSCC	SLC1A5 →	+0.574	+0.202	<.001	<.001	3	5
LSCC	ANTXR2 →	-0.549	-0.180	.003	.008	3	5
HNSC	CHRDL1 →	-1.289	-0.211	.002	.006	3	5
LSCC	UNC5A →	-0.535	-0.225	.001	<.001	3	5
LSCC	C1QTNF2 →	-0.550	-0.242	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032329 vs P4HA3 — OV

Explore this scatter interactively →