Serine transport

Across TCGA cell cohorts, RNA activity of the Serine transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT1E, PDLIM4, and SIX4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MT1E grouped by Serine transport-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MT1E →	+7.175	+1.533	<.001	.006	2	6
KIDNEY	PDLIM4 →	+3.478	+1.809	.001	<.001	3	5
BONE	SIX4 →	+1.768	+2.497	.006	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	RMDN2 →	+1.290	+1.794	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF549 →	+1.205	+1.627	.007	.006	3	4
UPPER_AERODIGESTIVE_TRACT	DCAF1 →	+1.445	+1.764	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MT1E by Serine transport activity — LIVER

Explore this box plot interactively →