Serine transport

Across TCGA cell cohorts, RNA activity of the Serine transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYSF, PEX7, and IFIT3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serine transport activity versus DYSF in LIVER (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DYSF →	+3.161	+0.170	<.001	<.001	3	6
BONE	PEX7 →	-0.706	-0.325	.003	.002	2	6
PANCREAS	IFIT3 →	+2.475	+0.176	<.001	.008	3	5
CNS	LRRFIP2 →	+1.145	+0.244	.001	<.001	3	5
LIVER	CDC42EP3 →	+3.381	+0.134	.001	.006	3	5
LIVER	SH3TC2 →	+1.785	+0.170	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032329 vs DYSF — LIVER

Explore this scatter interactively →