Alanine transport

Across TCGA patient cohorts, RNA activity of the Alanine transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBM47, NELFB, and PLTP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alanine transport activity versus RBM47 in OV (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RBM47 →	-0.275	-0.042	.007	.009	3	6
LSCC	NELFB →	-0.219	-0.077	.002	<.001	3	5
CCRCC	PLTP →	+0.404	+0.034	.006	.003	3	5
HNSC	KIAA0930 →	+0.170	+0.071	.002	<.001	3	5
UCEC	HNRNPA2B1 →	-0.098	-0.054	<.001	.002	3	5
LUAD	QPCT →	+0.662	+0.040	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032328 vs RBM47 — OV

Explore this scatter interactively →