Alanine transport

Across TCGA patient cohorts, RNA activity of the Alanine transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APBB1, RASL12, and CHRDL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alanine transport activity versus APBB1 in HNSC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	APBB1 →	-0.931	-0.487	<.001	.008	3	6
CCRCC	RASL12 →	-0.760	-0.734	<.001	.001	3	5
BRCA	CHRDL1 →	-1.807	-0.491	<.001	.001	3	5
HNSC	PHF1 →	-0.746	-0.447	<.001	<.001	3	5
HNSC	PGM5 →	-0.871	-0.443	<.001	.002	3	5
LUAD	ENPP4 →	-0.328	-0.408	.006	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032328 vs APBB1 — HNSC

Explore this scatter interactively →