Prostaglandin secretion

Across TCGA patient cohorts, RNA activity of the Prostaglandin secretion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LCN2, PLA2G4A, and AKAP8L, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostaglandin secretion activity versus LCN2 in GBM (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LCN2 →	+1.350	+0.078	<.001	.004	3	8
LUAD	PLA2G4A →	+0.794	+0.056	<.001	<.001	3	8
LUAD	AKAP8L →	-0.187	-0.045	<.001	<.001	3	7
GBM	PNN →	-0.357	-0.078	<.001	<.001	3	7
BRCA	CHERP →	-0.252	-0.037	<.001	.001	3	7
OV	HNRNPR →	-0.355	-0.047	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032310 vs LCN2 — GBM

Explore this scatter interactively →