Prostaglandin secretion

Across TCGA patient cohorts, RNA activity of the Prostaglandin secretion pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, PTGS2, and THEMIS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostaglandin secretion activity versus PLA2G4A in COAD (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLA2G4A →	+1.566	+0.716	.002	<.001	3	7
LUAD	PTGS2 →	+1.754	+0.301	<.001	<.001	3	4
GBM	THEMIS2 →	+0.679	+0.186	<.001	<.001	3	4
GBM	KLHDC8A →	-1.070	-0.210	.004	.003	3	4
GBM	RNF149 →	+0.448	+0.175	<.001	<.001	3	4
GBM	RNA5SP434 →	+0.401	+0.158	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032310 vs PLA2G4A — COAD

Explore this scatter interactively →