Prostaglandin secretion

Across TCGA patient cohorts, RNA activity of the Prostaglandin secretion pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLA2G4A_S434, PLA2G4A_S437, and PLA2G4A_S727, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostaglandin secretion activity versus PLA2G4A_S434 in COAD (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLA2G4A_S434 →	+0.959	+0.989	<.001	<.001	3	7
LSCC	PLA2G4A_S437 →	+1.086	+0.301	<.001	<.001	3	7
UCEC	PLA2G4A_S727 →	+0.925	+0.327	<.001	<.001	3	7
UCEC	PLA2G4A →	+0.860	+0.254	<.001	<.001	2	6
OV	PTGS2 →	+1.742	+0.293	.004	.001	1	6
LUAD	ABCC4_S404 →	+0.789	+0.442	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032310 vs PLA2G4A_S434 — COAD

Explore this scatter interactively →