Prostaglandin secretion

Across TCGA cell cohorts, RNA activity of the Prostaglandin secretion pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRHPR, DKK3, and GNAI2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRHPR grouped by Prostaglandin secretion-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GRHPR →	-1.140	-1.267	<.001	.002	3	4
BLOOD_Lymphoma	DKK3 →	-0.505	-0.392	.007	.002	2	5
LIVER	GNAI2 →	-1.027	-1.763	.004	.006	3	4
STOMACH	AKAP13 →	-0.914	-0.930	<.001	.006	3	4
CNS	TRAF1 →	-1.028	-0.915	.003	.001	3	4
CNS	PPM1F →	-0.785	-0.951	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRHPR by Prostaglandin secretion activity — KIDNEY

Explore this box plot interactively →