Prostaglandin secretion

Across TCGA cell cohorts, RNA activity of the Prostaglandin secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTP1, NCR2, and DLST, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RTP1 grouped by Prostaglandin secretion-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RTP1 →	+0.381	+0.255	.001	.004	3	4
SKIN	NCR2 →	+0.111	+0.822	.007	<.001	3	3
BLOOD_Leukemia	DLST →	+0.383	+0.931	.003	.004	3	3
BLOOD_Myeloma	PKMYT1 →	-0.183	-1.328	.001	.001	2	4
SOFT_TISSUE	SLIRP →	-0.223	-0.951	.005	.006	3	3
UPPER_AERODIGESTIVE_TRACT	TBCB →	+0.194	+1.315	.002	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RTP1 by Prostaglandin secretion activity — KIDNEY

Explore this box plot interactively →