Icosanoid secretion

Across TCGA patient cohorts, RNA activity of the Icosanoid secretion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SART1, KHDRBS1, and PNN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Icosanoid secretion activity versus SART1 in GBM (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SART1 →	-0.218	-0.072	<.001	<.001	3	6
GBM	KHDRBS1 →	-0.287	-0.055	.001	.003	3	6
GBM	PNN →	-0.352	-0.066	<.001	<.001	3	6
GBM	ZFR →	-0.246	-0.081	<.001	<.001	3	6
GBM	NBEAL2 →	+0.391	+0.080	<.001	<.001	3	6
GBM	CAV1 →	+0.768	+0.058	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032309 vs SART1 — GBM

Explore this scatter interactively →