Icosanoid secretion

Across TCGA patient cohorts, RNA activity of the Icosanoid secretion pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, DRAM1, and RNF149, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Icosanoid secretion activity versus PLA2G4A in UCEC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLA2G4A →	+1.825	+0.261	<.001	.001	3	6
GBM	DRAM1 →	+0.600	+0.341	<.001	<.001	3	5
GBM	RNF149 →	+0.393	+0.234	.003	<.001	3	5
LUAD	PTGS2 →	+1.503	+0.260	<.001	<.001	3	4
GBM	RBM4B →	-0.326	-0.248	.004	.006	3	4
GBM	CTSB →	+0.608	+0.238	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032309 vs PLA2G4A — UCEC

Explore this scatter interactively →