Regulation of prostaglandin secretion

Across TCGA patient cohorts, RNA activity of the Regulation of prostaglandin secretion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGAM, CCDC88B, and AMPD3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of prostaglandin secretion activity versus ITGAM in GBM (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ITGAM →	+0.803	+0.081	<.001	<.001	3	8
GBM	CCDC88B →	+0.384	+0.081	<.001	<.001	3	7
GBM	AMPD3 →	+0.655	+0.084	<.001	<.001	3	7
GBM	NCF2 →	+0.640	+0.074	<.001	<.001	3	7
GBM	PRAM1 →	+0.569	+0.091	<.001	<.001	3	7
GBM	APOBR →	+0.645	+0.113	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032306 vs ITGAM — GBM

Explore this scatter interactively →