Regulation of prostaglandin secretion

Across TCGA patient cohorts, RNA activity of the Regulation of prostaglandin secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, PNMA1, and PACERR, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of prostaglandin secretion activity versus PLA2G4A in LUAD (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLA2G4A →	+1.527	+0.304	<.001	<.001	3	8
LSCC	PNMA1 →	-0.523	-0.257	.007	.001	3	5
UCEC	PACERR →	+0.894	+0.308	<.001	<.001	3	5
LSCC	STAB2 →	+0.333	+0.204	.008	.003	3	4
LUAD	PTGS2 →	+1.552	+0.199	<.001	<.001	3	4
GBM	ZMYND15 →	+0.372	+0.240	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032306 vs PLA2G4A — LUAD

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