Regulation of prostaglandin secretion

Across TCGA cell cohorts, RNA activity of the Regulation of prostaglandin secretion pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2U1, NOL9, and OTUD4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP2U1 grouped by Regulation of prostaglandin secretion-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CYP2U1 →	+0.661	+0.598	.007	.008	3	3
LARGE_INTESTINE	NOL9 →	+0.813	+1.084	.002	<.001	3	3
LARGE_INTESTINE	OTUD4 →	+0.673	+0.968	.007	.003	3	3
LARGE_INTESTINE	MIER1 →	+0.890	+0.981	<.001	.003	3	3
LUNG_NSCLC_LUSC	TATDN1 →	+0.830	+0.860	<.001	.004	3	3
OESOPHAGUS	RABGGTB →	+0.896	+1.515	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP2U1 by Regulation of prostaglandin secretion activity — LARGE_INTESTINE

Explore this box plot interactively →