Regulation of prostaglandin secretion

Across TCGA cell cohorts, RNA activity of the Regulation of prostaglandin secretion pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM209, PNRC2, and RPS18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of prostaglandin secretion activity versus TMEM209 in SKIN (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMEM209 →	+0.761	+0.147	.002	.001	3	3
LARGE_INTESTINE	PNRC2 →	+1.218	+0.328	.001	.003	3	3
LARGE_INTESTINE	RPS18 →	+1.084	+0.362	.005	.002	2	4
STOMACH	RNASEL →	-2.250	-0.179	.006	.009	2	3
STOMACH	SEC61A1 →	-0.957	-0.135	.003	.003	3	2
STOMACH	MECOM →	-3.295	-0.135	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032306 vs TMEM209 — SKIN

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