Regulation of icosanoid secretion

Across TCGA patient cohorts, RNA activity of the Regulation of icosanoid secretion pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, PACERR, and UTRN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of icosanoid secretion activity versus PLA2G4A in COAD (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLA2G4A →	+1.868	+0.627	<.001	<.001	3	8
UCEC	PACERR →	+0.988	+0.327	<.001	.001	3	5
GBM	UTRN →	+0.311	+0.223	.009	.001	3	4
GBM	RNF149 →	+0.499	+0.173	<.001	.003	3	4
LSCC	PTGS2 →	+1.607	+0.276	<.001	<.001	3	4
GBM	SFT2D2 →	+0.268	+0.204	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032303 vs PLA2G4A — COAD

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