Regulation of icosanoid secretion

Across TCGA cell cohorts, RNA activity of the Regulation of icosanoid secretion pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF711, CYP1B1, and EBP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF711 grouped by Regulation of icosanoid secretion-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF711 →	+1.683	+0.791	<.001	.005	3	4
LARGE_INTESTINE	CYP1B1 →	+1.650	+0.847	<.001	<.001	3	3
SKIN	EBP →	-1.451	-1.195	.006	<.001	3	3
BLOOD_Lymphoma	CPLX1 →	+2.559	+0.518	.001	.003	3	3
BLOOD_Lymphoma	UVRAG →	+1.583	+0.418	.004	.006	3	3
BREAST	MMP24OS →	-1.569	-0.733	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF711 by Regulation of icosanoid secretion activity — STOMACH

Explore this box plot interactively →