Regulation of icosanoid secretion

Across TCGA cell cohorts, RNA activity of the Regulation of icosanoid secretion pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF184, POLR2J3, and EIPR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of icosanoid secretion activity versus ZNF184 in LARGE_INTESTINE (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF184 →	+0.702	+0.149	<.001	.005	3	5
LUNG_SCLC	POLR2J3 →	+1.299	+0.096	.002	.001	3	4
LUNG_NSCLC_LUAD	EIPR1 →	+0.834	+0.213	.001	<.001	3	4
SKIN	YBEY →	+0.556	+0.119	.004	.009	3	4
KIDNEY	TP63 →	-0.090	-0.155	.006	.001	3	4
UPPER_AERODIGESTIVE_TRACT	ARRB2 →	+0.913	+0.177	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032303 vs ZNF184 — LARGE_INTESTINE

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