Axon ensheathment in central nervous system

Across TCGA patient cohorts, RNA activity of the Axon ensheathment in central nervous system pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNA5SP190, CDC6, and TBCCD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axon ensheathment in central nervous system activity versus RNA5SP190 in LSCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RNA5SP190 →	+0.323	+0.499	.004	.002	3	4
OV	CDC6 →	-0.587	-0.519	<.001	.001	3	4
PDAC	TBCCD1 →	-0.241	-0.597	.006	.002	3	3
PDAC	MAGOH →	-0.259	-0.553	.008	.005	3	3
GBM	RPL6P24 →	-0.210	-0.338	.004	.003	3	3
PDAC	IGF2BP2 →	-0.518	-0.619	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032291 vs RNA5SP190 — LSCC

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