Axon ensheathment in central nervous system

Across TCGA cell cohorts, RNA activity of the Axon ensheathment in central nervous system pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA7, DYNLT1, and SH3BGRL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPATA7 grouped by Axon ensheathment in central nervous system-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SPATA7 →	-1.018	-1.301	.001	<.001	3	4
OESOPHAGUS	DYNLT1 →	-1.052	-0.947	<.001	.004	3	4
LUNG_SCLC	SH3BGRL →	+2.930	+1.124	.008	.004	2	5
OESOPHAGUS	TNFAIP1 →	-0.876	-0.764	.005	.002	3	3
LUNG_NSCLC_LUSC	PRKAA1 →	-0.486	-1.042	.002	.001	3	3
SKIN	PDCD6 →	-0.479	-0.845	.009	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPATA7 by Axon ensheathment in central nervous system activity — STOMACH

Explore this box plot interactively →