Axon ensheathment in central nervous system

Across TCGA cell cohorts, RNA activity of the Axon ensheathment in central nervous system pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCC1L, CRCP, and SMPD4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axon ensheathment in central nervous system activity versus RCC1L in OVARY (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RCC1L →	-0.918	-1.049	<.001	.001	3	4
OESOPHAGUS	CRCP →	-1.062	-1.721	<.001	<.001	3	4
BLOOD_Myeloma	SMPD4 →	-0.754	-2.273	.005	<.001	2	5
OVARY	POM121 →	-0.742	-0.931	.002	.006	3	4
LUNG_NSCLC_LUAD	MICAL2 →	-1.706	-0.990	<.001	.001	3	4
BLOOD_Leukemia	TMEM59 →	+1.227	+2.124	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032291 vs RCC1L — OVARY

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