Central nervous system myelin formation

Across TCGA patient cohorts, RNA activity of the Central nervous system myelin formation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNTN1, S100A10, and SEPTIN11, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Central nervous system myelin formation activity versus CNTN1 in GBM (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CNTN1 →	+0.924	+0.139	<.001	<.001	3	7
BRCA	S100A10 →	+0.501	+0.049	<.001	<.001	3	5
PDAC	SEPTIN11 →	+0.329	+0.074	<.001	<.001	3	5
BRCA	TLN2 →	+0.497	+0.051	<.001	<.001	3	5
PDAC	UNC5B →	+0.488	+0.056	<.001	.001	3	5
PDAC	VCAN →	+0.798	+0.064	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032289 vs CNTN1 — GBM

Explore this scatter interactively →