Central nervous system myelin formation

Across TCGA patient cohorts, RNA activity of the Central nervous system myelin formation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPAN, GOLGA8G, and LINC00989, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Central nervous system myelin formation activity versus PPAN in LSCC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPAN →	+0.366	+0.138	<.001	.005	3	4
OV	GOLGA8G →	-0.011	-0.767	<.001	.007	3	3
CCRCC	LINC00989 →	-0.413	-0.431	.007	.007	3	3
HNSC	TRMU →	+0.371	+0.263	.005	.005	3	3
LSCC	SMC6 →	+0.393	+0.136	.002	.005	3	3
HNSC	CFAP20DC →	+0.445	+0.251	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032289 vs PPAN — LSCC

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