Central nervous system myelin formation

Across TCGA cell cohorts, RNA activity of the Central nervous system myelin formation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEURL4, PELP1, and ZNF582, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEURL4 grouped by Central nervous system myelin formation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NEURL4 →	-0.962	-1.450	.001	<.001	3	4
CNS	PELP1 →	-0.382	-0.656	.001	.008	3	4
LUNG_NSCLC_LUSC	ZNF582 →	-1.092	-1.031	.007	.005	3	4
SKIN	RNASEK →	-0.396	-0.878	.004	<.001	3	4
LUNG_SCLC	VSTM2L →	-1.914	-1.233	.002	<.001	3	4
PANCREAS	SMDT1 →	+0.698	+0.937	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEURL4 by Central nervous system myelin formation activity — LUNG_SCLC

Explore this box plot interactively →