Myelin assembly

Across TCGA patient cohorts, RNA activity of the Myelin assembly pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN2, ANK2_S890, and MAP1A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myelin assembly activity versus TLN2 in PDAC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TLN2 →	+0.508	+0.059	<.001	<.001	3	8
UCEC	ANK2_S890 →	+0.957	+0.059	<.001	<.001	3	8
GBM	MAP1A →	+0.553	+0.107	<.001	<.001	3	8
LSCC	MAP1B →	+0.826	+0.048	<.001	<.001	3	8
GBM	ITSN1 →	+0.285	+0.107	<.001	<.001	3	8
UCEC	MYLK →	+0.833	+0.060	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032288 vs TLN2 — PDAC

Explore this scatter interactively →