Myelin assembly

Across TCGA cell cohorts, RNA activity of the Myelin assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTG2, IQCC, and KRT10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTG2 grouped by Myelin assembly-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MTG2 →	+0.584	+0.593	.001	.007	3	4
LUNG_SCLC	IQCC →	-1.076	-1.039	.004	.008	3	4
UPPER_AERODIGESTIVE_TRACT	KRT10 →	-0.902	-1.104	.002	.001	3	4
LUNG_NSCLC_LUSC	MBOAT7 →	-1.412	-1.329	<.001	<.001	3	3
LUNG_NSCLC_LUSC	ASS1 →	+2.765	+1.102	.004	.008	3	3
OESOPHAGUS	SCAMP5 →	+1.865	+1.052	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTG2 by Myelin assembly activity — BREAST

Explore this box plot interactively →