Myelin assembly

Across TCGA cell cohorts, RNA activity of the Myelin assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDCP, ZNF136, and MMACHC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myelin assembly activity versus WDCP in PANCREAS (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	WDCP →	-0.702	-1.127	.001	.001	3	4
PANCREAS	ZNF136 →	-0.496	-1.057	.008	<.001	3	4
LIVER	MMACHC →	-1.068	-1.347	.001	.007	3	3
LIVER	GCLM →	+2.148	+1.793	.009	.001	3	3
CNS	C3orf49 →	-0.121	-1.182	.002	.001	3	3
LUNG_SCLC	POU3F2 →	-1.703	-0.842	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032288 vs WDCP — PANCREAS

Explore this scatter interactively →