Negative regulation of gonadotropin secretion

Across TCGA patient cohorts, RNA activity of the Negative regulation of gonadotropin secretion pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJA1, INHBA, and PMEPA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of gonadotropin secretion activity versus GJA1 in OV (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GJA1 →	+1.619	+0.908	<.001	<.001	3	6
OV	INHBA →	+2.068	+1.260	<.001	<.001	3	5
OV	PMEPA1 →	+1.495	+1.114	<.001	.001	3	5
OV	ITGA5 →	+1.174	+0.838	<.001	.006	3	5
OV	LINC01615 →	+0.493	+1.054	<.001	.001	3	5
GBM	CDC25A →	-0.977	-0.430	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032277 vs GJA1 — OV

Explore this scatter interactively →