Negative regulation of gonadotropin secretion

Across TCGA cell cohorts, RNA activity of the Negative regulation of gonadotropin secretion pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJA1, NACAD, and INHBA, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of gonadotropin secretion activity versus GJA1 in LIVER (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GJA1 →	+6.069	+1.807	<.001	<.001	3	18
STOMACH	NACAD →	+0.760	+1.100	.004	.002	3	7
STOMACH	INHBA →	+2.986	+1.474	<.001	<.001	3	7
STOMACH	FRMD6 →	+2.926	+1.511	.009	.003	3	6
SKIN	CCN1 →	+2.798	+1.363	<.001	<.001	3	6
LARGE_INTESTINE	CSRP2 →	+2.334	+1.348	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032277 vs GJA1 — LIVER

Explore this scatter interactively →