Regulation of gonadotropin secretion

Across TCGA patient cohorts, RNA activity of the Regulation of gonadotropin secretion pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACTN1, MYH9_S1340, and PARVA, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gonadotropin secretion activity versus ACTN1 in OV (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ACTN1 →	+0.338	+0.060	.005	.007	2	9
CCRCC	MYH9_S1340 →	+0.597	+0.151	<.001	<.001	3	8
BRCA	PARVA →	+0.498	+0.090	<.001	<.001	3	7
BRCA	FERMT2 →	+0.580	+0.076	<.001	<.001	3	7
CCRCC	PRKG1 →	+0.511	+0.099	<.001	<.001	3	7
BRCA	DPYSL3 →	+0.579	+0.067	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032276 vs ACTN1 — OV

Explore this scatter interactively →