Regulation of gonadotropin secretion

Across TCGA cell cohorts, RNA activity of the Regulation of gonadotropin secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF84, CARD10, and EIF2S3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF84 grouped by Regulation of gonadotropin secretion-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNF84 →	-0.146	-0.819	.007	.001	3	4
LUNG_NSCLC_LUSC	CARD10 →	-0.278	-1.957	<.001	<.001	3	3
LUNG_SCLC	EIF2S3 →	-0.335	-1.258	<.001	.003	3	3
LUNG_SCLC	LCNL1 →	-0.227	-1.391	.001	<.001	3	3
BLOOD_Myeloma	PSTPIP1 →	-0.307	-2.413	.006	<.001	2	4
LARGE_INTESTINE	ADCY8 →	-0.105	-1.035	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF84 by Regulation of gonadotropin secretion activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →