Regulation of gonadotropin secretion

Across TCGA cell cohorts, RNA activity of the Regulation of gonadotropin secretion pathway is significantly associated with the drug response of multiple features, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are GW441756, VX-702, and Telomerase Inhibitor IX, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GW441756 grouped by Regulation of gonadotropin secretion-low versus -high activity in KIDNEY.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GW441756 →	-0.544	-0.304	<.001	.019	2	1
KIDNEY	VX-702 →	+0.094	+0.270	.028	.015	2	1
KIDNEY	Telomerase Inhibitor IX →	-0.674	-0.304	.038	.019	2	1
KIDNEY	NG-25 →	+0.830	+0.270	.008	.015	2	1
KIDNEY	TL-1-85 →	+0.638	+0.270	.004	.015	2	1
KIDNEY	Pelitinib →	+1.464	+0.304	.022	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GW441756 by Regulation of gonadotropin secretion activity — KIDNEY

Explore this box plot interactively →