Negative regulation of protein polymerization

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein polymerization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B9D1, C1orf159, and HIRIP3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, B9D1 grouped by Negative regulation of protein polymerization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	B9D1 →	-1.055	-0.185	.001	.003	3	3
LUNG_NSCLC_LUSC	C1orf159 →	+0.966	+0.208	.002	.007	3	3
LUNG_NSCLC_LUSC	HIRIP3 →	+1.248	+0.218	.002	.001	3	3
LIVER	TCIM →	+3.333	+0.218	.005	.003	3	3
LIVER	HYAL2 →	+0.718	+0.281	.002	<.001	3	3
CNS	FCSK →	+0.466	+0.602	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

B9D1 by Negative regulation of protein polymerization activity — OESOPHAGUS

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