Negative regulation of protein polymerization

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein polymerization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAZ1, COPS8, and ERGIC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein polymerization activity versus OAZ1 in BLOOD_Leukemia (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OAZ1 →	+0.535	+0.166	.002	.009	3	6
LUNG_NSCLC_LUSC	COPS8 →	+1.112	+0.416	.005	<.001	3	5
LUNG_NSCLC_LUSC	ERGIC1 →	+1.735	+0.472	.005	<.001	3	4
LUNG_NSCLC_LUSC	RAP1A →	+1.037	+0.418	.001	<.001	3	4
LUNG_NSCLC_LUSC	HERC3 →	+1.935	+0.393	.003	.005	3	4
LUNG_NSCLC_LUSC	ASAP2 →	+2.047	+0.350	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032272 vs OAZ1 — BLOOD_Leukemia

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