Regulation of protein polymerization

Across TCGA patient cohorts, RNA activity of the Regulation of protein polymerization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL10A, RPL5, and SEPTIN4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein polymerization activity versus RPL10A in LUAD (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL10A →	-0.192	-0.020	<.001	<.001	3	9
GBM	RPL5 →	-0.204	-0.062	<.001	<.001	3	9
GBM	SEPTIN4 →	+0.572	+0.041	<.001	<.001	3	9
BRCA	SSC5D →	+0.785	+0.030	<.001	<.001	3	9
OV	TNS2_S120 →	+0.684	+0.031	.001	.006	3	9
OV	CNRIP1 →	+0.651	+0.049	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032271 vs RPL10A — LUAD

Explore this scatter interactively →