IMP salvage

Across TCGA patient cohorts, RNA activity of the IMP salvage pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC11C, COLGALT1, and GAB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IMP salvage activity versus SEC11C in LSCC (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEC11C →	-0.713	-0.044	<.001	<.001	3	7
GBM	COLGALT1 →	+0.601	+0.106	<.001	<.001	3	6
GBM	GAB1 →	-0.349	-0.087	<.001	<.001	3	6
LUAD	MAP7D1_S70 →	+0.515	+0.077	<.001	<.001	3	6
GBM	SPP1_S195 →	+1.138	+0.112	<.001	<.001	3	6
HNSC	TXNDC5 →	-0.555	-0.077	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032264 vs SEC11C — LSCC

Explore this scatter interactively →