IMP salvage

Across TCGA patient cohorts, RNA activity of the IMP salvage pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AMPD2_S168, DENND1C_S480, and WAS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IMP salvage activity versus AMPD2_S168 in PDAC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	AMPD2_S168 →	+0.537	+0.127	<.001	<.001	3	6
HNSC	DENND1C_S480 →	+0.791	+0.209	<.001	<.001	3	5
GBM	WAS →	+0.460	+0.150	<.001	.001	3	5
GBM	AMPD2_S100 →	+0.608	+0.171	<.001	<.001	3	5
UCEC	STK10_S514 →	+0.963	+0.195	<.001	<.001	3	4
UCEC	WIPF1 →	+0.432	+0.148	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032264 vs AMPD2_S168 — PDAC

Explore this scatter interactively →