IMP salvage

Across TCGA cell cohorts, RNA activity of the IMP salvage pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INTS4, WSB1, and TRAPPC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INTS4 grouped by IMP salvage-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	INTS4 →	+0.456	+0.243	.002	.007	3	5
KIDNEY	WSB1 →	-0.156	-0.147	.004	<.001	3	4
LUNG_SCLC	TRAPPC3 →	-0.401	-0.297	<.001	<.001	3	4
OESOPHAGUS	ZSCAN10 →	-0.228	-0.173	<.001	.004	3	4
OESOPHAGUS	TMEM67 →	+0.106	+0.165	.001	<.001	3	4
LIVER	LRCH4 →	-0.192	-0.149	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INTS4 by IMP salvage activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →