IMP salvage

Across TCGA cell cohorts, RNA activity of the IMP salvage pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HPRT1, PSMA3, and PSMA7, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IMP salvage activity versus HPRT1 in LUNG_SCLC (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HPRT1 →	+1.740	+0.483	<.001	.002	3	17
LIVER	PSMA3 →	+1.250	+0.530	.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	PSMA7 →	+1.312	+1.262	<.001	<.001	3	16
OVARY	PSMD4 →	+1.146	+0.895	<.001	<.001	3	16
OVARY	PSMA5 →	+1.158	+0.841	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	PPP2R1A →	+1.129	+1.468	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032264 vs HPRT1 — LUNG_SCLC

Explore this scatter interactively →