GMP salvage

Across TCGA patient cohorts, RNA activity of the GMP salvage pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NGDN_S143, DDX52, and VWA5A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GMP salvage activity versus NGDN_S143 in OV (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NGDN_S143 →	+1.120	+0.061	.002	<.001	3	8
LSCC	DDX52 →	+0.477	+0.102	<.001	<.001	3	7
BRCA	VWA5A →	-0.445	-0.051	<.001	<.001	3	7
BRCA	AKAP12_S627 →	-1.157	-0.086	<.001	.001	3	7
BRCA	CEBPZ →	+0.322	+0.055	<.001	<.001	3	7
BRCA	DDX21 →	+0.568	+0.062	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032263 vs NGDN_S143 — OV

Explore this scatter interactively →