GMP salvage

Across TCGA patient cohorts, RNA activity of the GMP salvage pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADA, MAP4K1, and LINC00426, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GMP salvage activity versus ADA in HNSC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ADA →	+0.625	+0.115	<.001	<.001	2	8
UCEC	MAP4K1 →	+0.954	+0.148	<.001	<.001	3	6
UCEC	LINC00426 →	+0.825	+0.111	.001	.002	3	5
OV	WASL-DT →	-0.545	-0.331	.003	.004	3	5
HNSC	TBX21 →	+0.752	+0.118	.003	.001	3	5
UCEC	IL21R →	+0.695	+0.092	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032263 vs ADA — HNSC

Explore this scatter interactively →