GMP salvage

Across TCGA cell cohorts, RNA activity of the GMP salvage pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMPD2, ADA, and ADK, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GMP salvage activity versus AMPD2 in LUNG_NSCLC_LUSC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AMPD2 →	+1.248	+0.149	.005	.009	3	13
BLOOD_Leukemia	ADA →	+1.626	+0.116	<.001	<.001	3	13
SKIN	ADK →	+0.988	+0.106	<.001	<.001	3	12
OVARY	LOXL2 →	+3.224	+0.180	<.001	<.001	3	9
OVARY	RFLNB →	+1.112	+0.092	.007	.001	3	9
BLOOD_Myeloma	PFKP →	+3.023	+0.148	.005	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032263 vs AMPD2 — LUNG_NSCLC_LUSC

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