GMP salvage

Across TCGA cell cohorts, RNA activity of the GMP salvage pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIT1, MYC, and ANKRD13B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GMP salvage activity versus GIT1 in BLOOD_Leukemia (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GIT1 →	+0.500	+0.208	<.001	<.001	3	6
OVARY	MYC →	+1.335	+1.177	.001	.007	3	6
STOMACH	ANKRD13B →	+2.102	+1.157	.003	.006	3	5
BLOOD_Leukemia	UBIAD1 →	+0.515	+0.253	<.001	<.001	3	5
PANCREAS	TGFBRAP1 →	+0.683	+1.426	<.001	<.001	3	5
BLOOD_Leukemia	WDR33 →	+0.365	+0.140	.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032263 vs GIT1 — BLOOD_Leukemia

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