Purine nucleotide salvage

Across TCGA patient cohorts, RNA activity of the Purine nucleotide salvage pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL21R, CD4, and CCR5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleotide salvage activity versus IL21R in HNSC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IL21R →	+0.824	+0.159	<.001	<.001	3	6
LSCC	CD4 →	+0.730	+0.160	<.001	.001	3	6
HNSC	CCR5 →	+0.988	+0.203	<.001	<.001	3	6
HNSC	GIMAP8 →	+0.788	+0.132	<.001	.003	3	6
HNSC	PIK3CG →	+0.775	+0.162	<.001	<.001	3	6
HNSC	CD2 →	+1.045	+0.165	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032261 vs IL21R — HNSC

Explore this scatter interactively →