Purine nucleotide salvage

Across TCGA cell cohorts, RNA activity of the Purine nucleotide salvage pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VCL, BRIP1, and KLHDC8B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VCL grouped by Purine nucleotide salvage-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	VCL →	-1.199	-1.164	.002	.001	3	4
SOFT_TISSUE	BRIP1 →	+0.515	+1.045	.004	.001	3	4
STOMACH	KLHDC8B →	-1.745	-0.275	.006	.007	3	4
OVARY	TMEM62 →	+1.076	+0.864	.001	.005	3	4
KIDNEY	FAM169A →	-1.157	-0.741	<.001	.005	3	3
CNS	SLC7A6OS →	+0.405	+0.681	.005	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VCL by Purine nucleotide salvage activity — OVARY

Explore this box plot interactively →