Purine nucleotide salvage

Across TCGA cell cohorts, RNA activity of the Purine nucleotide salvage pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX11, MYC, and ALPP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleotide salvage activity versus COX11 in OVARY (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	COX11 →	+0.994	+1.877	<.001	<.001	3	6
BLOOD_Lymphoma	MYC →	+1.542	+0.234	.002	.004	3	5
LUNG_NSCLC_LUAD	ALPP →	-3.127	-0.829	<.001	.004	3	5
SKIN	LONRF3 →	+1.796	+1.191	<.001	.004	3	5
UPPER_AERODIGESTIVE_TRACT	CCDC32 →	+0.799	+1.364	.001	.005	3	5
UPPER_AERODIGESTIVE_TRACT	WDR33 →	+0.825	+1.865	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032261 vs COX11 — OVARY

Explore this scatter interactively →